Next, with the idea of killing with a single hit to the thigh or upper arm, well, I'm going to say yes, it is possible. Very possible. Catch is, though, it's not really possible the way it's been described. The only way you can do it is with a knife, or a machete, or a gunshot... anything that'll let you attack the femoral or brachial arteries (respectively), really. But I really don't think that's what you meant, so try to avoid using this as basis for your delusional ideas on martial arts effectiveness. You're really way off in huge ways.
What about a Bite?
I havent read up on anatomy for a while, and cant remember how far in the Arteries are.