Unless bullseye/target type shooting with a pistol, I'm of the opinion NPOA will nautrally have to be and should be ignored with a threat focused methodology.
Those who use front sight press are more apt to use a form of NPOA in their stance/feet and body alignment.
In defensive types of quick reactive shooting, one will be hard pressed to get into any stance, and stance is not situationally dependant to make combat accuracy effective. Taking the time to get into some form of ISO, MOD ISO, Weaver, etc to engage under the potential for incoming or taking incoming can be bad for your future health. SD training should work toward getting the students to shoot from non conventional positions, or in other words, from the position they find themselves in when they react to a threat with their handgun. This would include one handed shooting and can cover a wide degree of arc without having to turn the lower or upper body to alignment of threat.
Stand and deliver types of techniques like EU/ED, Zippers, Hammers, QK Hip, etc do make use of positioning the upper body and indexing the weapon through positioning, so they may make use of a loose form of NPOA in theory.
If the threat is moving, you are moving or both are moving, there should be no conscious effort made to get an NPOA, nor should there be reason to try as NPOA is used for one who is stationary and on stationary targets of opportunity, even if momentarily. The above is relevant to threat focused shooting techniques and would not be as true for a shooter using any form of their sights.
Edited to add as an afterthought about the rifles----
Quick Kill rifle [ threat focused ] does train the student to be stance specific initially as the system was developed for shotgunners and ariels. Over time, the position of the feet, upper body can be different as long as the shooter understands and is confident in the use of the references between the gun and threat that make the technique repeatable and reliable. This is most important where the rifle would snap into the shoulder from any position and the upper body would turret to engage without being stance specific.
Brownie