July 10, 2009 Birth Defect Study Casts Doubt on Phthalate Fears
Hypospadias is apparently not on the rise in the U.S., casting doubt on claims that phthalates and other endocrine disruptors cause reproductive abnormalities in humans
By Marla Cone and Environmental Health News
Scientific American
EXCERPT:
Hypospadias, one of the most common birth defects among baby boys, apparently is not increasing in the U.S., casting doubt on whether boys are harmed by phthalates and other endocrine-disrupting chemicals thought to trigger reproductive abnormalities.
Researchers have reported that the hypospadias rate stayed the same in New York State between 1992 and 2005. An earlier study also found no increase in California boys between 1984 and 1997.
Hypospadias, a condition in which the urethra opening is on the underside of the penis rather than the tip, occurs in roughly one of every 250 male births. Surgery is normally required or the condition can lead to infertility.
Some environmental scientists have suspected, based on studies of lab animals, that exposure to chemicals that block testosterone may be partially responsible for the birth defects.
In tests of lab rats, chemicals called phthalates, which are widely used in plastic and personal care products, cause several reproductive abnormalities that scientists have dubbed testicular dysgenesis syndrome" or "phthalate syndrome." Included are hypospadias, undescended testes, reduced sperm counts and testicular cancer.
In the new study, New York Presbyterian Hospital urologists said that because hypospadias rates are stable, it casts doubt on whether human boys are harmed by phthalates or other endocrine-disrupting chemicals.
The researchers reported in the journal Urology that these data suggest that the testicular dysgenesis syndrome described in animal models may not be evident in humans. The lead author was Dr. Harry Fisch, director of the hospitals Male Reproductive Center and a professor of clinical urology at Columbia University.
But other experts say the study does not invalidate the theory.
The evidence seems to suggest that there hasn't been a big increase in hypospadias over recent years, which does weaken the argument that new endocrine disruptors in the environment are causing hypospadias, said Kim Harley, a University of California, Berkeley epidemiologist who studies environmental exposures and human health but was not involved with the study.
Nevertheless, she added that it doesnt rule out that phthalates or other chemicals have a role in causing the defects. Looking at how birth defect rates change over time is not an adequate way of examining environmental connections.
END EXCERPT
From Dictionary.com:
Hypospadias is apparently not on the rise in the U.S., casting doubt on claims that phthalates and other endocrine disruptors cause reproductive abnormalities in humans
By Marla Cone and Environmental Health News
Scientific American
EXCERPT:
Hypospadias, one of the most common birth defects among baby boys, apparently is not increasing in the U.S., casting doubt on whether boys are harmed by phthalates and other endocrine-disrupting chemicals thought to trigger reproductive abnormalities.
Researchers have reported that the hypospadias rate stayed the same in New York State between 1992 and 2005. An earlier study also found no increase in California boys between 1984 and 1997.
Hypospadias, a condition in which the urethra opening is on the underside of the penis rather than the tip, occurs in roughly one of every 250 male births. Surgery is normally required or the condition can lead to infertility.
Some environmental scientists have suspected, based on studies of lab animals, that exposure to chemicals that block testosterone may be partially responsible for the birth defects.
In tests of lab rats, chemicals called phthalates, which are widely used in plastic and personal care products, cause several reproductive abnormalities that scientists have dubbed testicular dysgenesis syndrome" or "phthalate syndrome." Included are hypospadias, undescended testes, reduced sperm counts and testicular cancer.
In the new study, New York Presbyterian Hospital urologists said that because hypospadias rates are stable, it casts doubt on whether human boys are harmed by phthalates or other endocrine-disrupting chemicals.
The researchers reported in the journal Urology that these data suggest that the testicular dysgenesis syndrome described in animal models may not be evident in humans. The lead author was Dr. Harry Fisch, director of the hospitals Male Reproductive Center and a professor of clinical urology at Columbia University.
But other experts say the study does not invalidate the theory.
The evidence seems to suggest that there hasn't been a big increase in hypospadias over recent years, which does weaken the argument that new endocrine disruptors in the environment are causing hypospadias, said Kim Harley, a University of California, Berkeley epidemiologist who studies environmental exposures and human health but was not involved with the study.
Nevertheless, she added that it doesnt rule out that phthalates or other chemicals have a role in causing the defects. Looking at how birth defect rates change over time is not an adequate way of examining environmental connections.
END EXCERPT
From Dictionary.com:
The P,h and e are all silent.
