My 75 year old mother has reached the point where almost nothing works anymore. Her arthritis, not the kind that gives you an occasional ache, but the kind that makes you feel like someone is crushing your bones, along with her osteoporosis, her back is dissolving, have put her beyond the reach of most medicines. Celebrex, and others no longer work, codeine, combined with a bunch of other stuff, just touches it. Next step would be heroin, but not in the USA, she'll just have to suffer. I've actually thought about getting some on the street for her. Don't know if it would work, but the pain sometimes won't let her be.