I wear the flattest, thinnest soled shoes I can get in my size whenever I can, and for whatever I can. I make my own moccasins, wear the Walmart version of "kung fu shoes," wrestling shoes, and Merrell Barefoot Gloves for running the trails and hiking...the Vibram's don't come in real men's sizes, and the Merrell,s look enough like normal shoes that my dignity is preserved.
In any case, I've found it to be better for my balance, my knees, and my overall times for distances-I actually took more than an hour off of my 50 mile time, and I credit the whole thing to that small change in shoes (that and training up to it in them, of course.) It's especially easy on my knees. The funny part is that I've always been required to wear a variety of shoes, professionally, and the best part of my day is often getting to the car and taking off those steel toed boots and putting on nice, flat comfortable shoes......ahhhh!