Semaglutide - Cardiovascular Protection

[Gyakuto]

A large study on the effects of semaglutide strongly suggests it protects people from myocardial infarction and cerebrovascular accident beyond the weight loss benefits it provides! It may be as significant as statins have been in reducing heart disease!

What the results of Wegovy’s longest clinical trial yet show about weight loss, side effects and heart protection

New analyses of the longest clinical trial yet of the weight-loss drug Wegovy are shedding light on how quickly it helps people lose weight, how long they sustain that weight loss and how safe the medicine is over four years of use.

www.yahoo.com

https://www.jacc.org/doi/10.1016/j.jacc.2024.04.022

 

[Bill Mattocks]

A large study on the effects of semaglutide strongly suggests it protects people from myocardial infarction and cerebrovascular accident beyond the weight loss benefits it provides! It may be as significant as statins have been in reducing heart disease!

What the results of Wegovy’s longest clinical trial yet show about weight loss, side effects and heart protection

New analyses of the longest clinical trial yet of the weight-loss drug Wegovy are shedding light on how quickly it helps people lose weight, how long they sustain that weight loss and how safe the medicine is over four years of use.

www.yahoo.com

https://www.jacc.org/doi/10.1016/j.jacc.2024.04.022

I've been following this news. It is possible that other GLP-1 agonists such as Tirzepatide (Mounjaro), which I take, may offer the same cardiac benefits; studies are ongoing. As a heart patient with heart failure and Atrial Fibrillation, I'm very interested. I also take a statin, and Metformin, so I have a bunch of 'miracle drugs' working for me, much good it's done.

On the other hand, I have currently been without Mounjaro for over a month, as there is a nationwide shortage. The same is true of Semaglutide. It seems that the popularity of these drugs for weight loss have caused a nationwide run on them, and the manufacturers are completely out for people who need them diabetes such as my wife and myself.

This is the new reality of prescription drugs. In addition to the nearly 10,000 dollar cost PER MONTH of my diabetes and heart medications (currently covered minus the first $6K per year by my insurance), many drugs are in short supply currently. Some of my drugs are literally life-threatening if I suddenly withdraw from them, and yet that is exactly what is happening. My wife spends a good part of her day calling around to all the pharmacies in a 100 mile radius tracking down the prescription drugs we need. What a world.

 

[Gyakuto]

I've been following this news. It is possible that other GLP-1 agonists such as Tirzepatide (Mounjaro), which I take, may offer the same cardiac benefits; studies are ongoing.

Yes, I thinkmit is GLP-1agonists that have this beneficial effect.

As a heart patient with heart failure and Atrial Fibrillation, I'm very interested. I also take a statin, and Metformin, so I have a bunch of 'miracle drugs' working for me, much good it's done.

Well it’s impossible to know how you’d be if you weren’t taking those drugs.

On the other hand, I have currently been without Mounjaro for over a month, as there is a nationwide shortage. The same is true of Semaglutide. It seems that the popularity of these drugs for weight loss have caused a nationwide run on them, and the manufacturers are completely out for people who need them diabetes such as my wife and myself.

That’s very surprising. They can be obtained here on the NHS but it’s useful to order them at least a week before the patient needs them. Our pharmacists do all the phoning around to obtain them.

This is the new reality of prescription drugs. In addition to the nearly 10,000 dollar cost PER MONTH of my diabetes and heart medications (currently covered minus the first $6K per year by my insurance), many drugs are in short supply currently.

It’s the same here in the U.K. but I thought this was due to Brexit; we’re at the end of the very end of the queue when the EU is handing out stuff so we do miss out on the more important items.

Some of my drugs are literally life-threatening if I suddenly withdraw from them, and yet that is exactly what is happening.

I know of people being unable to obtain chemotherapy medication for their cancer treatments result in a delay to their treatment. Also anti-epileptic and HRT drugs are in short supply.

My wife spends a good part of her day calling around to all the pharmacies in a 100 mile radius tracking down the prescription drugs we need. What a world.

My neighbour discovered a breast lump last week. She had all her investigations performed, CT scan, staging report, Pick line insertion and then her first dose of chemo yesterday…7 days after she discovered it! I was very impressed.

 

[Gyakuto]

There is now evidence semaglutide may reduce cancer risk by a fifth!

 

[Bill Mattocks]

There is now evidence semaglutide may reduce cancer risk by a fifth!

I am hoping to hear similar news about tirzepatide soon, since it is also a GLP-1 agonist. In the meantime, I'm consoled by the fact that Metformin is shaping up to be a bloody wonder drug in a class with aspirin. I take 2,000 MG a day.

 

[Gyakuto]

I am hoping to hear similar news about tirzepatide soon, since it is also a GLP-1 agonist. In the meantime, I'm consoled by the fact that Metformin is shaping up to be a bloody wonder drug in a class with aspirin. I take 2,000 MG a day.

I’m sure it has the same effects since it’s a very similar drug in terms of stereochemistry. You’ll live until you 150, Bill…doubly explosively incontinent, but 150 nevertheless.

 

[Bill Mattocks]

I’m sure it has the same effects since it’s a very similar drug in terms of stereochemistry. You’ll live until you 150, Bill…doubly explosively incontinent, but 150 nevertheless.

I hope not. I can't afford to live much past 70.

 

[Bill Mattocks]

@Gyakuto, you express shock, but please understand I have no death wish. What I do have is a desire to protect my wife from being bankrupted by my medical expenses in the last few years of life. In the USA, those are the most expensive days of one's life; not to mention the most painful and humiliating. I would prefer to be hit by a bus while I am still ambulatory, given the choice. What would I miss? The adult-diaper wearing, dialysis and wheelchair days of being fed through a tube and drooling on myself, whilst my retirement nest egg vanishes into the pockets of businesses who pay their executives in amounts that exceed the budget of many countries, whilst leaving my wife in penury? I think I'll pass, thanks.